Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain
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چکیده
منابع مشابه
Human insulin vesicle dynamics during pulsatile secretion.
In healthy individuals, plasma insulin levels oscillate in both fasting and fed states. Numerous studies of isolated pancreata and pancreatic islets support the hypothesis that insulin oscillations arise because the underlying rate of insulin secretion also oscillates; yet, insulin secretion has never been observed to oscillate in individual pancreatic beta-cells. Using expressed fluorescent ve...
متن کاملThe decline in pulsatile GH secretion throughout early adulthood in mice is exacerbated by dietary-induced weight gain.
The transition between puberty and adulthood is accompanied by a slowing in linear growth. Although GH is a key factor that drives somatic development into adulthood, early adulthood coincides with a reduction in circulating levels of GH. To this extent, a pathological decline in postpubertal GH secretion is detrimental to attainment of peak lean muscle mass and bone mass and promotes adiposity...
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Anthropometric parameters are an important indicator of health and nutritional status comprising the whole span of mans life. However, they are not of the same degree of simplicity and sensitivity in assessing the public health status. During recent decades many studies have attempted to examine the relationships of these measurements in order to present simple alternatives for similar purposes...
متن کاملPostprandial suppression of glucagon secretion depends on intact pulsatile insulin secretion: further evidence for the intraislet insulin hypothesis.
Type 2 diabetes is characterized by an approximately 60% loss of beta-cell mass, a marked defect in postprandial insulin secretion, and a failure to suppress postprandial glucagon concentrations. It is possible that postprandial hyperglucagonemia in type 2 diabetes is due to impaired postprandial insulin secretion. To address this, we studied eight adult Goettingen minipigs before and after an ...
متن کاملDifferential pulsatile secretagogue control of GH secretion in healthy men.
Pulsatile growth hormone (GH) secretion putatively reflects integrated regulation by GH-releasing hormone (GHRH), somatostatin (SST), and GH-releasing peptide (GHRP). GHRH and SST secretion is itself pulsatile. However, how GHRH and SST pulses act along with GHRP to jointly determine pulsatile GH secretion is unclear. Moreover, how testosterone (T) modulates such interactions is unknown. These ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2013
ISSN: 0022-0795,1479-6805
DOI: 10.1530/joe-13-0084